Mary Katherine Goddard -- Publisher
In Colonial America, when most women were raising children and keeping homes in what was then a pretty hard-living New England, Mary Katherine Goddard was acting as the first-ever female postmaster and using her business to further the American Revolution.
In 1777, when no other publisher would touch it, Goddard fearlessly published the first copy of the Declaration of Independence that included the names of its drafters, making herself a member of the rebellion and making the rebellion a sure thing: The signers could no longer back out. While she would never achieve the wealth boasted by the other women entrepreneurs on this list, she earns a high rank for using her business skills to help change history.
Up next: Not even prison could slow her down.