Dishonesty on a job interview can sabotage your chances of getting the job. If you don't know the answer to a question, say so. A bluff is not likely to work. For example, when you're asked whether you've had experience with a particular type of software, don't say you're familiar with it if you aren't. The interviewer may ask further questions that reveal your lie. Instead, be truthful but mention that you're a quick study when it comes to learning new skills.
Don't pad your résumé or include outright lies. Emphasize your accomplishments on previous jobs or at school, but don't exaggerate. You could be tripped up later if the interviewer checks on your record. Giving credit to colleagues and to those who helped you is always a good tactic.
You should prepare ways to spin things like employment gaps, frequent moves or weakness in your education or skills. You might explain that you were pursuing volunteer work or taking time off because of family obligations. If you don't have formal training, mention that you've learned more through experience than you might have in school.